Get an overdrive transmission. Best of both worlds. Why compromise? If you have a 4-gear, passon makes an o/d gearset or you could do a 70's/80's o/d 833 for cheap. If that doesn't sound appealing, play with this calculator:

http://vexer.com/68rt/speed.html

I've got 3.55's and a 727 and it's basically 3000rpm at 65mph. Livable but I don't like to see my motor revving that high needlessly so I have an overdrive trans in the garage waiting for me to get to it.