It would require some super computer time to figure out the answer to that question. My guess is that a really high quality 4.250 stroke rotating assembly will last longer than a low quality 3.75 stroke rotating assembly. I've seen this at the engine shop over the years where guys with super high dollar rotating assemblies just come in every few years for a ring change and everything looks perfect. But the blocks with the cheap Chinese rotating parts are usually beat to heck. Bearings beat up, main caps beat up, studs loose in the block, etc. The cheap stuff seems like it destroys itself over time while the Callies and better parts just spin like watches.

Not sure I can provide a technical explanation for that, but I've seen it many times.