I would look at it a different way. As in, what is your goal?

ET/MPH at what weight or power at what rpm?

I think it's been said but basically as you raise compression, if everything else is optimized for it, you will make more power as you narrow your tuning window.

Said in another way, less room for error.

If I was building what I think you're trying to build I would do twin turbo and methanol.