My experience;

1976 Power Wagon, 318, 727, NP203, runs like new. Have replaced spark plugs, ECU, ballast resistor, alternator, starter, water pump, all filters/fluids, brakes, tires, etc.
No major repairs, ever. My Dad bought new.

2004 Ram 1500 Quad Cab, 5.7L Hemi, 5 spd auto, Fulltime 4wd, ran great, no issues. My Dad bought new. Traded in 2008 for a new 2008 when they were rebated heavily and offering the lifetime powertrain warranties.
2008 Ram 1500 Quad Cab, 5.7L Hemi, 5 spd auto, fulltime 4wd, Dad bought new, passed away in 2012 but that truck is still in the family, runs great.

2011 Ram 1500 Quad Cab, 5.7L Hemi, 5 spd auto, fulltime 4wd, my first new truck. Bought new in Nov 2011 and still daily drive. I have replaced brake pads, tires, batter (once), spark plugs, ATF and filter, air and oil filters, and once had a "loss of power" issue that turned out to be a faulty Variable Cam solenoid (fixed under warranty). Solid and reliable, I drive every day, and have moved with this truck twice, pull a boat regularly (in the summer months), pull trailers regularly (all year) and have never had a pulling issue, still has the original water pump, starter, alternator, battery lasted until July 5th, 2018, and with 130,000+ miles, I'd consider this to be a very reliable vehicle. Driven in NW Iowa all year, in snow/ice, mud, dirt roads, gravel roads, and parked outside (I have a 3 car garage and 6 cars). The Ram sits outside, and still no issues.

JS