It’s hard for me to imagine there being any kind of PV clearance issues running a 221@.050/112lsa cam in a 440 with pistons down the hole .140.

I did it with a stock 68 short block(pistons down the hole .055), 346 heads that had been milled a bit and steel shim gaskets

68 Satellite, 383 with stock 906’s, 3550lbs, 11.18@123
Dealer for Comp Cams/Indy Heads