In my experience, an 850 would be a cork in that combo. My 500 was a bit milder than your combo and I started with an 850. Tried a 950 and went faster. Tried a 1050 Dominator and went faster still.

I also have a 1050 on my 540 Hemi. Both combos were primarily street.

Thumper can put a 1050 together for you that will rival any self tuning throttle body EFI. And certainly will start, run, and drive better than any OOTB carb, whether it is a 4150 or 4500 platform.

A Thumper carb will cost more than a generic carb, but a lot less than an EFI set-up and with fewer mods to the rest of the fuel system.