If you buy a TBI EFI system, and it self tunes, then you might as well just run a carb. To maximize the potential of EFI, you need sequential multi-port EFI, and to have a custom tune written either by yourself or a paid expert. Generic self learning won't take into account your combustion chamber shape, compression ratios, quench values, cam timing, etc in the timing tables. It may do a good job at hitting 12.5:1 at WOT and 14.7:1 at part throttle cruise, but that's like tuning your engine and never touching the distributor.

Not to mention the advantages to a dry manifold over a wet one, and a TBI is still a wet manifold.