I dont see a problem with either choice as far as integrity goes but I would get quench if you have closed chamber heads or mill the recesses in the open chambered heads then work with plateau pistons to achieve it if you want to go that far (its time/money but worth it). #1 quench (if you can) #2 cam choice (one that you can live with) (3) octane choice) (4) SCR to get the DCR in a good range so you can run a fast ign curve & be under the pinging line. As said detonation will kill any of em (not to mention any names but some quicker than others!).