Basically if you need more than studs and aluminum caps...you probably need an aftermarket block.  It can't hurt, but I personally wouldn't bother. I'd use aluminum caps with studs and run it. I'm going to test the limits soon of a stock block 440 w/ a stock crank and caps, ARP bolts. The motor is in the 680-700 hp range. Once I get it dialed in N/A, I'll turn on the plate.
CHIP
'70 hemicuda, 575" Hemi, 727, Dana 60
'69 road runner, 440-6, 18 spline 4 speed, Dana 60
'71 Demon, 340, low gear 904, 8.75
'73 Chrysler New Yorker, 440, 727, 8.75
'90 Chevy 454SS Silverado, 476" BBC, TH400, 14 bolt
'06 GMC 2500HD LBZ Duramax
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