To the OP, there must be a dozen of these engines on the board and they are significantly stouter feeling than a 383. Do it!

To whoever is worried about crank journal overlap, it has been a concern. It was a real concern for the OEMs especially using cast cranks. Thus you got the 2.81" main size on the 360 and the 2.65" main size on the chevy 400. HOWEVER, seeing that huge bigblockchevy engines are running stock 2.75" mains and 2.200" rod journals with 5.25" strokes and more, with zero journal overlap, it seems the 4340 cranks are strong enough so that doesn't matter as much.

R.

SO, OP, Do it! build that 3.75" stroke 383.