If it is iron headed with a stock(ish) cam and has true 10.5:1 I would expect some difficulty. 9.5:1 would be a typical target for pump gas/iron head.

I guess it will like 100 octane. Tricks to help are cold air intake, slow timing curve and limit total mechanical advance. That may do it on pump gas.

If it is not "quench" now a thick head gasket can get compression down and help.