Am I right in thinking that the advertised rpm range of big block camshaft would be lower if the cam was used in a 500 cubic inch stroker? If so, by how much would it be lower?
Does the same apply for the advertised RPM range of an intake?

Yes on the cam and somewhat on the intake would be my guess

You need to spread the lobe center for the extra cubes...

Thanks for the replies, anyone else have an opinion?

I'd say yes and yes. A bigger displacement (say 440 to 500) will lower the RPM range of the cam. I don't have an exact number but 200-300 RPM would be in the ball park.

A consiration is the head flow potential. The stroker will want more air; with standard port heads if that's what you're running, you'll probably run out of flow by 6000 RPM max. Camming much beyond that point will just make the engine a dog.

Same comment on the manifold to a point. Another impact on the manifold is sheer cubes and torque. A single plane on a stroker may have a bit less low/mid-range compared to a "big" dual plane like a performer RPM but still more than enough to roast street tires in 1'st and 2'nd. In that case, might as well enjoy the top end benefit of the single plane since it gives more than enough low/mid range punch.