i agree an old Holley would probably have been better out of the box, but if you want to work on this one, its possible to do.
A lot of good information on
http://racingfuelsystems.myfunforum.org/ as well as the archived innovate and MSV forums.
There's some things that are important to understand so you figure out what is the logical items to test and adjust. The main jets have little to no effect on idle, off-idle, and light steady throttle. The 'idle circuit' provides the fuel mix during those conditions as well as deceleration.
However the idle circuit responds slowly to change in throttle and load, and that's where the accelerator pump comes in.
If the engine is surging at interstate speeds, say 60 - 65 mph and up, then the main jets are the primary fuel restriction and and a little richer jetting is needed in that situation. The main jets plus the power valve restrict the fuel during wide open throttle - and under full load being too lean can cause damage. So on the drag strip, I prefer to work in from the rich side as long as the plugs aren't getting carbon fouled!
I completely agree that cleaning or replacing these should be done first. I'd probably clean them if they're not too bad. Then once idle and very gentle off-idle acceleration are working and not fouling the plugs, put in a fresh set.
IMO the best explaination and diagrams of how a Holley works are in Urich and Fisher's
Holley Carburetors and Manifolds and the second best is Urich's 4150/4160 book. Both published by HP Books. You don't need the latest versions, a used copy will do fine. Vizzard's new book is more thorough in some ways, but in doing so, I think its not as good an introduction to the basic concepts. Also if you follow Vizzard too closely sometimes you end up going down wrong paths. Been there. Some of that is IMO the format of SA Design books.