I would not open up the feed hole to the #1 main. I would however open the feed hole up to 9/32" on #2,#3 and #4, but again leave #5 alone. The feed hole to #2,#3 and #4 mains feed 2 rods each and #1 and #5 only feed one rod each, so the hole should remain the same to help more oil to go to #2, #3 and #4. If running a solid flat tappet or roller, I would also turn the oil off to the drivers side lifters by plugging the hole that feeds it. It has the access hole outside the block opposite the oil pressure gauge hole. Some worry about turning oil off to the drivers side but I have done it many times with out any issues. You could drill a .04 hole in the plug so the driver side lifters see a small amount of oil. One last thing I also would do, is drill a new .080 hole in the cam bearings on the opposite side of the hole already there. Then line up your new .080 hole with the hole in block. You can only do the #4 cam bearing if you are externally oiling the rockers such as Indy Heads.