Lots of folks run a 295/50 on a 10 with no problem. Just make sure you get your backspacing right on the rim... typically 5 to 5-1/2. You'll have to check your own clearances for that.

As far as the axle info is concerned... take a look over here at MyMopar.com
http://www.mymopar.com/Mopar8_75RearEndGuide.htm