This was my second year running E85. 2008 with a carb, and 2009 with the Ron's Flying Toilet mechanical injection. I love it. Runs great, cheapest hot rod fuel around. It is slightly cheaper than pump 87 octane gas.
http://www.e85prices.comMy Combo:
4.250" stroke, 4.375" bore, 511 CID in a low deck 400 block
Indy 440-1 heads, 68cc, giving 13.5 CR
Indy 400-3 intake (single 4-barrel dominator)
Comp Cams solid lifter MM305S-10, 279/287, 0.650"/0.630", 110 LSA
2-1/8" x 32" x 4" collector headers
I only use summer grade E85, 82-85% ethanol. Ask the station owner for the delivery sheet to make sure the ethanol to gas percentage is right. Avoid the winter grade which could be as low as 70-75% (suitable for lower CR); and will also change the tune up needed.
You will need to deliver about 30% more fuel than gasoline, so make sure your system is up to it. Check this forum:
http://www.e85forum.com