I have a 73 duster running 29.5 x 10.5's. The 1/4 panel front of the tire has been cut when I bought the car. Raced it for about a year that way. Now I am in the process of making the wheel well bigger and still retain the stock look. I am thinking of putting in the same tire or going with 30 x 9's. If I go with the 10.5's I'm going to have to narrow the axle about 1 inch each side. I've got lots of pictures and details on my blog.

No you don't have to do anything to the 1/4 panel behind the tire - theres plenty of room there. Its only the front that has problems because Ma Mopar decided to make the 1/4 panels curve inwards towards the tire there... :-(