i have been using anti-seize on plugs forever, it seems. just a dab is all i use, and i don't use a two foot cheater bar to torque them down.
with plugs that have been in use for eleventythousand miles, i run the engine to get some heat in the heads, then "feel" what it wants for the plug to break loose.
sometimes, i have "bad feelings" before the plug finally breaks loose...........