As much compression as you can make...16 to 1 is by all means not out of line on methanol. I have the understanding more compression = milder camshaft also when dealing with methanol or should I say an easier on parts type of camshaft. I am no rocket scientist but will be shooting for as much compression as I can get into my combo and it is injected alky. But there is alot of people that think over 14 to 1 is a waste...