How high of a compression ratio are you wanting to know about?
I shoot for 10.5 or less with aluminum heads on customers motors, 9.5 or less with iron heads
I have a 505 C.I. 400 block that has a little over 11.3 to 1 compression ration due to the 440-1 heads having little tiny 50 CC combustion chambers
I haven't ran that motor in a car yet but I'm hoping the camshaft, 262@.050 intake and 263 @.050 on the exhaust lobes ground on a 105 LSA will drive okay with no pinging
My street pump gas stroker motor in my Duster started off with a set of mildly ported big valve 906 iron heads with 9.25 to1 compression that combination made my 3450 lb Duster run 10.69 at 124.+ MPH with a low deck six pack set up.
I switch the heads to a set of CNC ported Eddy RPM with the same size combustion chambers that had the same compression ratio, those heads made the car pickup so it ran 10.49 at 126 MPH
The next winter I swap the crankshaft from a 4.25 stroke to a 4.300 stroke to raise the compression ratio up to 10.29 to 1 and that picked the car up to run 10.30 at 127. MPH.
The last parts changed was another set of heads, Indy SR M.W. ports along with a Indy 400-1 intake and a 1050 CFM Holley Dominator carb, that ended with a best ET of 9.993 at 134.6 MPH