What is the Holley List # and dash cast into the choke horn ? I would look up the original stock specs. for that carb dash number, IE 4779-6 and jet it back to stock unless your more than 1500 Ft above sea level, if so then try one Holley # size smaller. for every 1000 Ft above sea level to get you in the ball park.
If your 4000 Ft above sea level and the stock primary jet was suppose to be a # 76 I would try a 72,73 or maybe even a 71.
Leave the secondary jetting alone until you get the primary side jetting and air bleeds and spark plug heat range and ignition timing set up exactly the way you love it!