It all depends on what you want out of the car.
The 300 will be more luxurious than the Charger
This is very inaccurate. Both cars can and could be ordered with varying trim model setups( interior/exterior/interior upgrades), do yourself a favor and test drive as many different trim optioned of both as you can. The 5.7 is no slouch in either, but both 6 liter engines are great. If you don't want to do a bunch of work to go fast, get an SRT. Fuel economy will vary based upon driving conditions. The charger I had, 5.7/2012, avg fuel economy was 29mpg, many long trips at 32mpg. The SRT will sip more.