I haven't used it, but a lot of guys around me do. There is about a .1 gain, and you can run more timing. All the guys running it are using vacuum pumps with it as well. It also requires a different cam I am told for the injection, but that may be for stacks.
Tuning window is bigger......BUT, for the money, and the hassle, I would never do it....I watch those guys struggle some days. Fuel goes bad, can't get it started, floods out, have to dump bad fuel and find fresh fuel...No thanks. Seems like a real PITA most weekends.
Now if I were to go E85 or Meth, it would be with a carb and a small vacuum pump. A lot less changes needed.