I wouldn't worry at all about losing flow with a carb that size. With dyno time I've done an annular makes up for most if not all of the power lost from less air due to better atomization and vaporization, that leads to better distribution. The 4150 style annular carbs use a booster that is .600 thru the center versus a .500 center a Dominator uses, which loses less flow. Have you considered something custom? When building I prefer the BLP baseplates, the t-slots are smaller which make the idle and part throttle smoother. Quick fuel bodies have a better entrance shape, they flow better on the flow bench than the Holley. BLP billet bodies are another good choice. And there is custom work that can be done with boosters to help flow and signal a little more, and improve atomization.