Should be fine. I'm running a 222/228, 107 lsa installed at 104 (whiplash cam). Lots of torque, good drivability, chops at idle, but only has 9" of vacuum.

My vacuum booster hasn't complained and I have plenty of power assist available.

Made 285 rwhp through a manual trans with stock heads. Pushed my 4000 lb truck to traction limited 14.5s at 99 mph.