I have dont it a couple of times with tires that had non repairable punctures in the sidewall or close to the sidewall.
Put a patch on the inside and a tube in it. No problems.
I agree with the others tho, it is most likely a rim leak. The local tire shop fixed the one on my jeep by cleaning the wheel and brushing on liquid cement, for rubber patches..
OR just slime it...and be done..