Yes it's safe. I ran 100LL AvGas in a 12.2:1 compression 440 on the street and strip for 3 or 4 years w/ no trouble. Not sure what the differences b/t the AvGas and Cam2 additives are, but I know you'll hear a lot of people say not to run it for various reasons. I can tell you from firsthand experience that it works great and is a cheap substitute to race fuel. CHIP