I ran 295/65s for years. Offset springs, a little trimming on the wheel lip molding, a 3/8" spacer in front of the front spring perch and custom back spacing on the 10" Cragars. The rear shackle hanger did rub some on the rear valance.

A little tip on the rims: If you need to order custom back spacing like I did, order them with about 1/4" too little inside spacing. They are not usually perfect. And it is a lot easier to space them out a bit than it is to move them in.