They will physically fit and work but you will lose quite a bit of compression and there will be basically no flow improvement as the bigger valve just barely clears the bores and is partially shrouded in the lower lift areas. If I was using a stock 5.7 bore I would not use the larger heads unless I had pistons to make up for the compression loss or was looking for a compression loss so I could run a bunch of boost or something. You can add a small notch to the bore to mitigate a little bit of the flow loss but you can't go very far with that because the ring is so high up on the piston, too big of a notch and you will lose compression past the ring and burn it up very quickly. Other than those concerns they are a direct bolt on for a 2009 and newer 5.7.