I'm sure this has been tried over the years, but please enlighten me.
The 4 inboard head bolt / head stud positions, can you make a wedge block accept Hemi heads ?
No You need the cast in holes for the inner head studs to seat against also
I know the main caps won't be the same.
Isn't the only really tricky part the 4 head bolt mounts?
NO, the push rods hit the block and would need grinding the valley a lot, some of the early Mopar Pro Stock racers tried doing that swap on 383 blocks, it didn't work back then either Is it possible, just not feasible or practical ?
Not feasible, my two cents
Even the motor mounts you can get around.