Probably one of the best ( power vs life expectancy) in the big inch Hemi world is the 572ci - 4.5 bore X 4.5 stroke. The alky classes have used 4.5 stroke for years as well. If those are any indicators for you . I have a 528 nach asp motor now that needs attention and an trying to convince my self NOT to make it a 572. Also have a 525ci Blown motor with a 4.5 crank so I guess I feel they're safe,

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'01 P1500, Blown/Inj BAE,/Veney ,Bruno/CS2,Dana 60
'01 Dodge 3500 S Cummins Auto, Fresh air kit, 4" Exhaust,
'05 Dodge Magnum R/T - Too Much to list
'60 Willys CJ5
'01 International LPX - Project,DT466, Allison
'64 Plymouth Valiant, Inj 528 Hemi, 2spd