Yes.
After an Allied bombing mission to flatten the largest Nazi synthetic fuel complex suffered very heavy losses,
it was decided not to go back and bomb it again.

This has been called “The Greatest Allied Mistake of WW-II”

The war in Europe could have ended at least one year earlier, and perhaps two years earlier.

American and British bombing planners knew that the synthetic fuel plants produced gasoline, and considered them equal to refineries.

They did not know that the synthetic plants also produced explosives and synthetic rubber.

Instead of bombing ball bearing factories, railroad crossings, or airplane factories
what German sites should have been bombed?

Answer: bomb the sites the Germans were protecting most heavily.

Later in the war when the synthetic plants were bombed flat,
Albert Speer went to Hitler and told him: You have less than 90 days before we will not have supplies to fight with.