I have a reall hodge-podge of wrenches, different brands ect. I have my drawer split into 5 areas with two peices sheetmetal bent into a wide-flat 'U' (or a 'C' channel...). I put everything smaller than 3/8 in the left side, everything larger than 7/8 on the right side. The middle three are split with three different sizes in each area, all are VERY easy to pick apart when you're searching.

Code
Less |  3/8   |  7/16  |  1/2  | Larger
Than |  9/16  |  5/8   | 11/16 | Than 
3/8  |  3/4   | 13/16  |  7/8  | 7/8


This'll sound a little dumb, but after you use it a while it works really easy.