I have a reall hodge-podge of wrenches, different brands ect. I have my drawer split into 5 areas with two peices sheetmetal bent into a wide-flat 'U' (or a 'C' channel...). I put everything smaller than 3/8 in the left side, everything larger than 7/8 on the right side. The middle three are split with three different sizes in each area, all are VERY easy to pick apart when you're searching.
Less | 3/8 | 7/16 | 1/2 | Larger
Than | 9/16 | 5/8 | 11/16 | Than
3/8 | 3/4 | 13/16 | 7/8 | 7/8
This'll sound a little dumb, but after you use it a while it works really easy.