Depends on what breaks first smile
Dropping a valve killed my 451 stroker.

I would think Detonation would be obvious, but that is more of a combination/tuning/fuel octane issue.
Something that can be done in the build is using lightweight parts. The mass of the piston and rod increases really fast with RPM. Also, a longer rod / higher rod ratio lowers acceleration and sideloading, but may be more prone to detonation?

I don't know how much hardblock helps in strength?

I have been told that aluminum rods and caps may help absorb some harmonics, but I don't have any info on that.

I think something like the BCR main (aluminum) caps and girdle help stabilize the bottom end, but don't know how much strength it adds?

Good balancing and machine work with proper clearances should be obvious.

Maybe some oiling modifications windage tray, or scraper, or drysump will reduce windage and oil whipping.

I think that is about all you can do with the stock blocks?