The 4.15" stroke crank with stock rod bearing size clears in my 400 block stroked to 500"
As mentioned, the 1/2" pickups with the large collar are a problem. I originally had a Milodon 1/2" pickup that cleared, then when I put the stud girdle on, I made my own pickup tube.
On the recent 505" 440 with 4.25" crank and 2.20 rod bearings, had to grind the collar on one of the 440 source pickups for clearance.
Both need a bit of grinding on the pickup tube boss in the block.
The 440 source H-Beam rods (RPM Brand) seem to have a bit more clearance than the old I-Beam rods did.