If the car won't hook up and the rear is in good shape then it should last, however I would upgrade to a Dana or S60.

I did a 440/500 build a few years ago.
440 Source stroker kit
Pro Form 850 DP carb
Edlebrock heads with mild port work
Holley SD intake
Hydraulic roller 242/248 at 50 and 589 lift
9.7: compression
MSD pro billet distributer

This combination made 570 HP at 5500 rpm and 633 torque at 4400 rpm

I can drive this car all day long with no issues. It is a very fun car to drive

Frank