No unless it has a A745. Will kill a A903 almost immediately. I have a spare 66 A745. Not sure if a A903 would even fit a big block - might.

Many 4 spd big block housings have a dual bolt pattern for both a 3 speed and a 4 speed.

I have a 383 3 spd on the column 65 Fury cop car. Nothing wrong with a 383 3 spd on the column!

Note - at least in 65 (think 66 is the same) A745 were different between small and big block. The 1st gear ratio is different.