I am not running a big motor like you have but I have been running a pretty much stock 727 with a manual valve body behind my small block that makes well over 600 hp. I have been running it for 5 years with no issues.

1.33 60 ft,6.21 at 110.59 in the 1/8, pump gas small block,2950lbs,drag radials,mufflers and driven to track ...