A 48-53 Dodge cab & front sheet metal can be mounted on a late model full size chassis, but the spacing between the front axle location, the motor placement and the cab firewall will interfere with each other. The older cabs and front sheet metal (up to about 60) are shorter, front to back, then the newer stuff 61-93) is. Also, the wheel track (tire to tire width) is wider (about 6") on the newer stuff then it was on the old stuff. Tire interference between the fender edge and the outside edge of the tire can become an issue.

I mounted a 50 cab & front sheet metal from a 2 ton truck on an 80 1/2 ton Dodge 4x4 chassis. The 80 motor set about 6" farther back on the frame then did the 50 motor sat on its frame. The 80 front axle set forward a few inches more then the 50 did on its chassis, and the frame overhang ahead of the front sheet metal was pretty significant. I had to cut the 80 frame off just in front of the 80's front crossmember and mount the front bumper there. To make it look right, I basically had to make front fenders by re positioning and re curving the fender extensions from my 50 front sheet metal (my 50 2 ton truck had 20" wheels, and the 80 4x4 chassis had 15" wheels). I pretty much shifted the wheel openings as far forward as I could on the 50 fenders.

The 50 cab sat forward of the original standard cab 80's rear cab mounts. I raised my 50 cab 6" off the frame so the motor would fit under the 50 complete firewall. Had I not lifted my cab, I would have had the full width of the back of the LA 360 motor 6" inside the firewall (or about even with the bottom of the 50s cab dash. The newer then 94 trucks have a longer nose then the 72-93 trucks.

If the OP is after a simpler frame swap, an 88-96 Dakota has a better engine on the frame setting then the full size trucks and would be a much better fit under a 52 truck cab, but then he will loose the big truck capacity. Gene