I went with the 499 stroked 400 block. I figured it would be easier on the engine block at high RPM (lighter weight, lower acceleration rates and loading when switching direction, less side wall thrust loading?)
Down side with the short piston might be piston rock/ring seal on the intake stroke?
You can get a 4.15" crank with the 2.20" rod journal, that will give a better selection of rods/rod lengths.
Currently using the Hughes CNC ported MW Victor heads. I did not cc the Hughes heads, but compression with 75cc should be around 12.4:1 with zero decked flat tops. I used the old 440 source stroker kit with I-Beam rods and ARP2000 bolts, and the BCR aluminum main caps with girdle.
Not too many runs on it, because of the issues with the old Victor heads. Just got it running with the new CNC heads and E-85 last year, so we'll see how this year goes?

I think the 4.25" stroke low deck is a good choice for most street/strip cars that are not going to run 7000+ RPM.

I do have the 4.25" crank in the 440 block in the convertible