My 2007 Ram 1500 5.7 has been a good truck, but there have been problems.
At 59,000 miles, one of the MDS lifters failed, hanging open at times when it shouldn't. They had to replace the lifter, hone the cylinder and replace the rings on the piston. $3700 later, it ran like new. I'm at 159,000 now. Heater/Air cond have been fine. I got 119,000 miles from the rear brake pads and 123,000 from the front. Pretty odd that the rears needed replacement before the fronts, huh?
The trans slips sometimes upon a cold start, but like an old school Torqueflite, after revving in neutral it pumps up and works fine. I still have the original starter, water pump, serpentine belt and tensioner.
Spark plug service is a pisser. Half the engine sits under the windshield, and #s 5 and 7 are underneath the windshield and brake booster. It takes me just under 2 hours to change the 16 plugs!