Mike in New Zealand here.
Anthony, here is a run-down of my set-up.
I run a Comp Cams solid,248@050"; 76 overlap on 110 centers. RB Stroker 496;10:8-1 with 187 lbs cranking pressure. I've champhered the top of the bore beside the inlet valve down to top of top ring.(I believe it helps Cylinder filling)
Stock 440 Source Stealth Heads; 1-7/8" Headers; Weiand Xcelerator with 850 Holley(4781).
It idles at 800rpm.
My car is an Australian Charger weighing with myself & fuel a nudge over 4000lbs.
I have New-Process 4-Speed with 2:75 geared 9inch out back.
It runs 12:00-12:25@117-118:50mph 1/4 mile & 91-92mph 1/8th mile with 2:0sec 60ft every run.
I use a 650(4777)Holley on the street & get 17 mpg Imperial. Thats probably about 15 mpg to a US Gallon.
Also; on a chassis dyno the 650 was only 13 HP down on the 850.
I suspect this is because the cam reads quite small in the stroker versus the 440.
Another thing also; the Cam! A 110 Lobe Seperation is probably better for you as well. Better drivability & I have 12 inches vacumn at idle & 18 inches @ 75mph.
I shift at 6000 as it's laying down by 5800 due to the cam being small for the engine size.
Also, all parts except the short block, including the cam, I use to run in a 440 prior to this build.
It went 13:00 @ 113mph. It also did 160mph measured in a Car Club Flying 1/4 Mile.
Incidentily; one day I arrived late for one of these flying 1/4's so did my first run with the 650 & it run through at 160 MPH & next run with the 850 did exactly the same speed.
The jets in the 850 are 77's as I had to lean it down from standard 80's to up the exhaust temps in the header probes. I have sensor plugs on each header about 4 inches from exhaust ports.
Probably because the rod ratio is more like a Big-Block Chev & creates more draw as the piston goes away from TDC faster I suspect why it needed leaning out.
I took a guess on what I could get away with on this combo so as to just run ordinary pump gas & because my "quench" is damn good,it is close to the limits of cylinder pressure.
Slightly big in cam choice would likely give more power, but being to small,& you might lose the engine because of detonation.
In the near future I'm going to get a set of Stealth CNC'ed Heads & up the cam to mid 250's@ 050 with over 0:600 lift as they seem to really up the Torque & Power.
Because it's mainly a street car is why I'm chasing Torque & good fuel consumption & not "all out 1/4 times.
My 2:75 gears only slow the first 60 to 80ft on launch & then it's long gears & great fun.
Hope this is of help & interest.