I wiped out a perfectly good roller cam in about 10 minutes on my x block w2 motor when I thought offset lifters would be a good idea...
but I had almost 1 inch offset on the rockers and 300 seat pressure, I bet it could be done but I wouldn't take that chance

-65 Valiant,420", all motor,2700#, dot tires, 8,42 @ 160,2