It can work but you are going to need a good radiator. You will also need a
very big oil cooler since most of the heat will be going into the oil. I bought a water/oil cooler that nascar uses. It removes 80,000btu's and my oil will still hit 220 on a hot summer day.
My next motor will have a KB aluminum block. Should have just done that in the 1st place. Granted my short filled block has been in my car for over 10 years at 740hp and 3,000 street miles/yr