There will be minor differences even with injectors at extreme placements/ angles. Even an optimized pattern/ angle/ distance is not going to be the best for the entire operating range of the engine.
If you favor great idle, get the injector as close to the intake valve as possible, and aim the injector angle at the intake valve head.
Idle will have the lowest air speed and air density. This means intake air will have much less effect on the shape of the injected fuel cone out of the injector. Sort of like adjusting for wind when target shooting, or peeing out of a car on the freeway😆
As density and air speed rise, injector angle gets less critical. The air will grab any fuel and move it where it wants to. The higher the rpm and density, the further from the intake valve the injector should be.
The best of both worlds is staged injection.

And we shouldn't overlook the effect of injector timing. This ability comes with sequential injection when you have both a Crank and Cam signal. At idle you want to inject well after the camshaft reversion pulse that pulses back into the intake runner. This primarily affects idle but it can be significant with a radical cam.