I have an 05 5.7 Magnum and its getting multiple cylinder misfire code along with like 4 other cylinder codes. It has had plugs, wires and coil packs with in the last year and a half. Could it be the computer. I have heard bad things about these computers.

Most common issue is a broken valve spring.

So far no broken valve springs. Burnt coils again.

Is the car as delivered or have you added any electronics? Boom box, speakers, amp, etc? Your PCM is a computer with several high capacity transistors driving the coils. Sometimes adding electronics to a car can create a ground plane fault that will not allow the coil drivers to go to zero. There's a lot more to it but the bottom line is it can create a lot of heat in the coils/wiring. A fresh coil can tolerate this for a while but the heat will get it sooner or later. It's why there's a warning about adding stuff to the electrical system of new cars. Good luck.

Factory everything on the inside. Only changes to it are fresh air and muffler delete.

Find someone with a diagnostic oscilloscope, I prefer a Pico. Take a look at whayts happening. A bad PCM will be readily evident. Save some money. Replacing parts to find a problem can really cost you.

Multiple misfire codes can go with a bad fuel pump , or in a charger you have a transfer pump too.Connect a fuel pressure gauge to it and drive around.