A 5" crank will phyically fit in a BB but the rods may hit the cam lobes. Also, you'd need 2.2" or smaller rod journels so your rods would clear the rest. (Still have to do some grinding for rod clearance) Must have external oiling as the pickup won't fit in there either. Now...a stock block wouldn't take the horsepower that that much displacement with the correct parts can generate. Normally with a 5" crank you're looking at a raised cam aftermarket block to make it all work.
I'm building a 605 Hemi presently, 4.75" crank. The cam has to be dialed in for the lobes to clear the rods. I'm using a MP siamese Hemi block.
Do yourself a big favor and get the aftermarket block. If I was doing it all over I'd buy a KB aluminum block. Dave