470" b engine. mopar performance 383/440 aluminum heads .590 cam M1 4500 flange with a 1050 2" tti's 10.5/1 34deg timing no vac adv. chrome box four speed

I am thinking it may be either an ignition problem or the carb, maybe it was just because it was real hot and humid and I havent reset the mixture screws on the carb since this spring?
This carb (1050 model 8082) has never been great, but has always worked o.k.