The wire wheel should help knock off the loose rust if there is any. In your case, I'd wipe a thin pass of wheel bearing grease on the inside bead of the wheel. I've done this on old tires and old wheels. It not only helps seal a little better, it makes the tire inflate and seat easier if you are using a compressor at home.
I saw on YouTube last night several videos of people using spray chemicals and a flame to inflate tires that have popped off the beads. Crazy, but none of these guys blew themselves up.