Availability of E85 in your area is part of the decision.
http://www.e85refueling.com/http://www.e85refueling.com/distance.php?page=1I love my switch to E85 in my race car. The mods were paid for by fuel cost savings from race gas in 1 season. Right now race 110 (VP) is $9.25 at the local track. In May I paid $2.09 for E85 and in July it was $2.29. Typically 5-20 percent cheaper than 87 octane pump gas!
13.5 CR, 279/287 at 0.050" cam, aluminum heads, flat top pistons, 0.039" quench. I ran a E85 carb in 2008 and got a good deal on a used Ron's flying toilet mechanical fuel injection ($800) for this year. I started injection with alky (methanol) and switched calibration over to E85.